Space Industry and Business News  
New HIV strain leapt to humans from gorillas: study

by Staff Writers
Paris (AFP) Aug 2, 2009
French virologists on Sunday said they had found a new subtype of the AIDS virus that appears to have jumped the species barrier to humans from gorillas.

The new strain, found in a woman from Cameroon, West Africa, is part of the HIV-1 family of microbes that account for the vast majority of cases of human immunodeficiency virus (HIV), they said.

Until now, all have been linked to the chimpanzee.

The new subtype has been called P, adding to three established HIV-1 subtypes -- M, by far the most prevalent, and O and N, which are rare.

There is also an HIV-2 which is a minority viral family and is also suspected to have origins in non-human primates.

The virus was sequenced from a blood sample taken from an unnamed 62-year-old woman who moved to Paris from Cameroon, according to a letter published by the journal Nature Medicine.

In 2004, shortly after moving to the French capital, the woman was tested for HIV. She responded to diagnostic tests for HIV-1 but further tests failed to pinpoint the viral subtype.

The virus was genetically decoded and then put through a computer model to compare its evolutionary past against known viruses, both HIV and its equivalent in apes, called simian immunodeficiency virus (SIV).

The strain was a "significant" match with SIVgor -- an immune deficiency virus found in gorillas.

"The most likely explanation for its emergence is gorilla-to-human transmission of SIVgor," the letter says.

The research was headed by Jean-Christophe Plantier at a national referencing laboratory for HIV at the Rouen Hospital Centre, northwestern France.

HIV is believed to have jumped from humans from their closest animal relatives more than a century ago, in west-central Africa.

Analysis of tissues preserved by doctors in the colonial-era Belgian Congo shows that HIV-1 began spreading among humans at some point between 1884 and 1924, according to an investigation published last October.

But until now, the known vector has been the chimpanzee.

Some experts have suspected that the gorilla may have been implicated in the N subtype, but this is the first time that a link has been so clearly defined.

"A gorilla origin is highly likely" in the new P subtype, Marie Leoz, one of the research team, told AFP.

"For the time being, it's the closest source. What is still quite difficult, though, is to date when the first transmission of the virus took place, because there are still very few gorilla strains that are available."

Leoz also said subtype P was probably rare among humans, but further work was needed to confirm this.

The Cameroonian woman has no sign of AIDS, is receiving treatment and has a stable count of viruses and of CD4 cells, a key benchmark of immune-system fitness, said Leoz.

There are several theories that seek to explain how SIV entered humans.

An infected animal bit a human, or a SIV-infected ape was butchered and sold for bushmeat, and the virus entered the bloodstream through tiny cuts in the hand, according to these hypotheses.

AIDS first came to public notice in 1981, when alert US doctors noted an unusual cluster of deaths among young homosexuals in California and New York.

It has since killed at least 25 million people, and 33 million others are living with the disease or HIV, the virus that destroys immune cells and exposes the body to opportunistic disease.

Share This Article With Planet Earth
del.icio.usdel.icio.us DiggDigg RedditReddit
YahooMyWebYahooMyWeb GoogleGoogle FacebookFacebook



Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola



Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News


EU seeks swine flu plan before schools reopen
Brussels (AFP) July 31, 2009
European Union nations struggled Friday to draw up a common strategy to confront swine flu before children return to school in September, increasing the risk the illness will spread. At a meeting in Brussels, EU health experts examined a British proposal to delay school re-openings until the end of September, to help buy time so vaccines and other responses can be prepared. Other ideas ... read more







The content herein, unless otherwise known to be public domain, are Copyright 1995-2009 - SpaceDaily. AFP and UPI Wire Stories are copyright Agence France-Presse and United Press International. ESA Portal Reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by SpaceDaily on any Web page published or hosted by SpaceDaily. Privacy Statement