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EPIDEMICS
Haiti death toll from cholera tops 4,000

Bacteria's defenses against vaccine found
London (UPI) Jan 28, 2011 - British scientists say they've found genetic clues to an evolutionary war between Streptococcus pneumoniae bacteria and vaccines and antibiotics that combat it. The study has identified the genetic events by which bacteria such as S. pneumoniae -- responsible for a number of human diseases including pneumonia, ear infection and bacterial meningitis -- respond rapidly to evolve resistance to new antibiotics and vaccines, ScienceDaily.com reported Friday. "Drug resistant forms of S. pneumoniae first came onto the radar in the 1970s," Stephen Bentley of the U.K. Wellcome Trust Sanger Institute says.

"We sequenced 240 samples collected over the course of 24 years from the PMEN1 lineage of S. pneumoniae. By comparing the sequences, we can begin to understand how this bacterium evolves and reinvents itself genetically in response to human interventions." The study shows S. pneumoniae is a pathogen that evolves and reinvents itself with remarkable speed, the researchers say. The scientists say the bacteria's genes for antigens -- the molecules that trigger human immune response -- can change those antigens in response to vaccines meant to deal with them. "If the immune system targets these antigens, then the bacteria can simply change them, like a criminal changing their appearance to evade detection," researcher William Hanage at the Harvard School of Public Health says.

Severe malnutrition after Pakistan floods: UNICEF
Islamabad (AFP) Jan 28, 2011 - The UN children's agency said on Friday that six months on from Pakistan's devastating floods, nearly a quarter of children in the worst-hit province of Sindh remain acutely malnourished. The results of a new provincial survey show the problem is critical, with 23.1 percent of children in the north and 21.2 percent of children in the south of Sindh recorded as acutely malnourished. UNICEF said the Sindh government estimates about 90,000 children aged 6-59 months are malnourished. "This rate is well above the World Health Organization's 15 percent emergency threshold level, which triggers a humanitarian response," UNICEF said in a statement.

"Children with severe acute malnutrition need immediate treatment," the agency said, adding that it was working with federal and provincial government authorities to reach and treat the children. Catastrophic monsoon rains that swept through the country in July and August affected 20 million people, destroyed 1.7 million homes and damaged 5.4 million acres of arable land. The UN launched a $2 billion flood relief appeal in September but still requires nearly half that amount, in particular to help farmers return to work after the waters devastated fields. The UN said about seven million people are still living on monthly food rations.
by Staff Writers
Port-Au-Prince (AFP) Jan 27, 2011
The death toll from Haiti's cholera epidemic has gone up to 4,030 more than three months after the disease broke out in the country's Artibonite valley, the health ministry said Thursday.

The number of cholera cases seen in Haiti totalled 209,034 as of January 24, the ministry said.

The severity of the epidemic has diminished over time, but the ministry's figures show that Haitians are still dying from the bacterial infection, which can strike swiftly with intense diarrhea and vomiting leading to dehydration and sometimes death.

In the latest wrinkle in the evolution of the epidemic, Haitian and international health officials are investigating a cluster of cases of paralysis in recovering cholera patients with days of being discharged from a treatment center.

"Experts including toxicologists are investigating possible contamination at a hospital or at home from medication, food, or another source as the cause of death in these cases," the Pan American Health Organization said.

Another possible cause is polio, it said, but officials believe that is highly unlikely because polio is rarely lethal and three of the four patients who suffered paralysis died.

The health crisis broke out in mid-October as Haiti was struggling to recover from a 7.0 magnitude quake in January that killed more than 220,000 people, left 1.3 million homeless, and the capital in ruins.

While the epidemic is subsiding in Haiti, Venezuelan authorities announced emergency measures Thursday after 452 Venezuelans were exposed to cholera at a wedding on Saturday in the Dominican Republic, which borders Haiti.

There were at least 37 confirmed cholera cases among Venezuelans returning from the wedding, and officials in Caracas were trying to track down more than 400 others known to have attended the event.

earlier related report
Haiti probes sudden deaths, paralysis cases
Port-Au-Prince (AFP) Jan 27, 2011 - As if a cholera epidemic were not enough, Haitian health authorities Thursday were investigating the sudden deaths of more than a dozen people after a voodoo ceremony and a deadly spate of paralysis in recovering cholera patients.

Ariel Henry, chief of staff of the Haitian health ministry, said epidemiologists were sent to the town of Fonds Baptiste, about 30 kilometers (18 miles) from Port-au-Prince, to investigate the large number of sudden deaths there.

"The victims were said to have died suddenly after being seized with strong migraines, vomiting and struck blind," Henry said, recounting reports from witnesses.

A nurse contacted by telephone by AFP said 16 people had died since the start of the week in the town.

Henry put the number of deaths at about a dozen, while Daniel Epstein, a spokesman with the Pan American Health Organization, said the exact number had not been determined yet.

"We are investigating two groups of deaths... that occurred after a voodoo ceremony," Epstein said, adding that they appeared to be from poisoning.

They may have consumed a homemade alcohol, or eaten fruit from the ackee tree, which contains a toxic compound that can be fatal if the fruit is not harvested and prepared correctly, he said.

Another doctor, who asked not to be identified, suggested the cause of death was probably ethanol poisoning. "The first data gathered show that they had drunk homemade brew," he said.

In a separate medical mystery, the Pan American Health Organization said Haitian and international health authorities were looking into four cases of paralysis in recovering cholera patients in the town of Port-de-Paix.

Three of the four patients died, and one is slowly recovering in a hospital in Port-au-Prince, it said.

"These patients, hospitalized for severe cholera, presented an ascending bilateral flaccid paralysis of acute onset 24 to 72 hours after the end of the cholera treatment," the agency said.

The cases were first reported on January 10 in Haiti's Nord-Ouest Department.

"All of the cases were seen at the same cholera treatment center and returned 2-4 days later with neurological symptoms, at which point they were hospitalized," the agency said.

"Experts including toxicologists are investigating possible contamination at a hospital or at home from medication, food, or another source as the cause of death in these cases," it said.

"Although considered highly unlikely, polio has not been completely ruled out, pending laboratory results of samples," it said.

The experts do not believe it is polio because the disease rarely causes death.



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